The Classical Structure Of Blood Biochemistry- A Mathematical Model
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Date
1966-07
Authors
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Journal ISSN
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Publisher
Rand Corporation
Abstract
Description
This
Memorandum, one of a series on the modeling of
blood biochemistry, describes, and examines the consequences
of, the classical analysis of human blood. Classically, the
macroscopic features of healthy blood--the principal fluid
and electrolyte distributions--can be said to be in a
hemostatic steady state under the influence of several
interacting constraints, e.g., the osmotic effects of the
fixed proteins, the (fixed) charge of the proteins and
the neutral electrostatic charge condition, and the active
cation pumps. Chapter I examines these constraints from the vantage of a theoretical model, and shows them to be sufficient
explanation for the steady state; whether they are
also necessary has not been demonstrated.
Chapter II considers the incorporation of the microscopic
properties of the proteins in the model, particularly
their buffering behavior. This work is not complete, owing
principally to the lack of firm data on hemoglobin.
Chapter III discusses the validation of the mathematical
model and the consequences of the previous biochemical structural
detail, testing the model under various conditions--
changes in,gas pressure and pH, and additions of a few chemical stresses. It compares several validation experiments with the literature. This Memorandum show that, except for certain interesting discrepancies, the model satisfactorily agrees with the literature.
Keywords
Blood Biochemistry, Mathematical Model, Proteins