Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework
Date
2015-04-20
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Publisher
Public Library of Science (PLOS)
Abstract
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific
protein complexes in an ontology framework that relates them both to their components and
to species-independent families of complexes. Comprehensive curation of experimentally
known forms and annotations thereof is expected to expose discrepancies, differences, and
gaps in our knowledge. We have annotated the early events of innate immune signaling mediated
by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting
ontology and annotation data set has allowed us to identify species-specific gaps in
experimental data and possible functional differences between species, and to employ inferred
structural and functional relationships to suggest plausible resolutions of these discrepancies
and gaps.
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Citation
Arighi C, Shamovsky V, Masci AM, Ruttenberg A, Smith B, Natale DA, et al. (2015) Toll- Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework. PLoS ONE 10(4): e0122978. doi:10.1371/journal.pone.0122978