Browsing by Author "Green, Matthew D."
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Item Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery(Royal Society of Chemistry, 2014-06-05) Green, Matthew D.; Foster, Abbygail A.; Greco, Chad T.; Roy, Raghunath; Lehr, Rachel M.; Epps, Thomas H. III; Sullivan, Millicent O.; Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, III and Millicent O. Sullivan; Green, Matthew D.; Foster, Abbygail A.; Greco, Chad T.; Roy, Raghunath; Lehr, Rachel M.; Epps, Thomas H. III; Sullivan, Millicent O.Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.