Browsing by Author "Leroux, S."
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Item A high-resolution radiation hybrid map of chicken chromosome 5 and comparison with human chromosomes(BioMed Central, 2004) Pitel, F.; Abasht, Behnam; Morisson, M.; Crooijmans, R. P.; Vignoles, F.; Leroux, S.; Feve, K.; Bardes, S.; Milan, D.; Lagarrigue, S.; Groenen, M. A.; Douaire, M.; Vignal, A.; Pitel, F., Abasht, B., Morisson, M., Crooijmans, R. P., Vignoles, F., Leroux, S., Feve, K., Bardes, S., Milan, D., Lagarrigue, S., Groenen, M. A., Douaire, M., Vignal, A.; Abasht, BehnamThe resolution of radiation hybrid (RH) maps is intermediate between that of the genetic and BAC (Bacterial Artificial Chromosome) contig maps. Moreover, once framework RH maps of a genome have been constructed, a quick location of markers by simple PCR on the RH panel is possible. The chicken ChickRH6 panel recently produced was used here to construct a high resolution RH map of chicken GGA5. To confirm the validity of the map and to provide valuable comparative mapping information, both markers from the genetic map and a high number of ESTs (Expressed Sequence Tags) were used. Finally, this RH map was used for testing the accuracy of the chicken genome assembly for chromosome 5.Item Using transcriptome profiling to characterize QTL regions on chicken chromosome 5(BioMed Central, 2009) Le Mignon, G.; Pitel, F.; Desert, C.; Leroux, S.; Demeure, O.; Guernec, G.; Abasht, Behnam; Douaire, M.; Le Roy, P.; Lagarrigue, S.; Le Mignon, G., Pitel, F., Desert, C., Leroux, S., Demeure, O., Guernec, G., Abasht, Behnam, Douaire, M., Le Roy, P., Lagarrigue, S.; Abasht, BehnamAlthough many QTL for various traits have been mapped in livestock, location confidence intervals remain wide that makes difficult the identification of causative mutations. The aim of this study was to test the contribution of microarray data to QTL detection in livestock species. Three different but complementary approaches are proposed to improve characterization of a chicken QTL region for abdominal fatness (AF) previously detected on chromosome 5 (GGA5).