Imaging the lower limb network in Parkinson’s disease
| Author(s) | Chung, Jae Woo | |
| Author(s) | Bower, Abigail E. | |
| Author(s) | Malik, Ibrahim | |
| Author(s) | Martello, Justin P. | |
| Author(s) | Knight, Christopher A. | |
| Author(s) | Jeka, John J. | |
| Author(s) | Burciu, Roxana G. | |
| Date Accessioned | 2023-06-27T20:11:42Z | |
| Date Available | 2023-06-27T20:11:42Z | |
| Publication Date | 2023-04-13 | |
| Description | This article was originally published in NeuroImage: Clinical. The version of record is available at: https://doi.org/10.1016/j.nicl.2023.103399. © 2023 The Author(s). Published by Elsevier Inc. | |
| Abstract | Background Despite the significant impact of lower limb symptoms on everyday life activities in Parkinson’s disease (PD), knowledge of the neural correlates of lower limb deficits is limited. Objective We ran an fMRI study to investigate the neural correlates of lower limb movements in individuals with and without PD. Methods Participants included 24 PD and 21 older adults who were scanned while performing a precisely controlled isometric force generation task by dorsiflexing their ankle. A novel MRI-compatible ankle dorsiflexion device that limits head motion during motor tasks was used. The PD were tested on their more affected side, whereas the side in controls was randomized. Importantly, PD were tested in the off-state, following overnight withdrawal from antiparkinsonian medication. Results The foot task revealed extensive functional brain changes in PD compared to controls, with reduced fMRI signal during ankle dorsiflexion within the contralateral putamen and M1 foot area, and ipsilateral cerebellum. The activity of M1 foot area was negatively correlated with the severity of foot symptoms based on the Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III). Conclusion Overall, current findings provide new evidence of brain changes underlying motor symptoms in PD. Our results suggest that pathophysiology of lower limb symptoms in PD appears to involve both the cortico-basal ganglia and cortico-cerebellar motor circuits. | |
| Sponsor | The authors would like to thank the participants for their time and commitment to this research and the National Institutes of Health (NIH R21 NS114816) for funding this study. | |
| Citation | Chung, Jae Woo, Abigail E. Bower, Ibrahim Malik, Justin P. Martello, Christopher A. Knight, John J. Jeka, and Roxana G. Burciu. “Imaging the Lower Limb Network in Parkinson’s Disease.” NeuroImage: Clinical 38 (January 1, 2023): 103399. https://doi.org/10.1016/j.nicl.2023.103399. | |
| ISSN | 2213-1582 | |
| URL | https://udspace.udel.edu/handle/19716/32949 | |
| Language | en_US | |
| Publisher | NeuroImage: Clinical | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| Keywords | Parkinson’s disease | |
| Keywords | BOLD | |
| Keywords | fMRI | |
| Keywords | force | |
| Keywords | lower extremity | |
| Title | Imaging the lower limb network in Parkinson’s disease | |
| Type | Article |
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