Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals
| Author(s) | Sheehan, Ana E. | |
| Author(s) | Bounoua, Nadia | |
| Author(s) | Stumps, Anna | |
| Author(s) | Miglin, Rickie | |
| Author(s) | Huerta, Wendy | |
| Author(s) | Sadeh, Naomi | |
| Date Accessioned | 2023-11-30T15:21:25Z | |
| Date Available | 2023-11-30T15:21:25Z | |
| Publication Date | 2023-09-07 | |
| Description | This article was originally published in Journal of Psychopathology and Clinical Science. © American Psychological Association, 2023. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. The final article is available, upon publication, at: https://doi.org/10.1037/abn0000857 | |
| Abstract | Self- and other-directed violence (SDV/ODV) contribute to elevated rates of mortality. Early trauma exposure shows robust positive associations with these forms of violence but alone does not distinguish those at heightened risk for later engagement in SDV/ODV. Novel assessment metrics could aid early identification efforts for individuals with vulnerabilities to violence perpetration. This study examined a novel neurobiological measure of impulsive choice for reward as a potential moderator of associations between childhood trauma exposure and lifetime SDV/ODV. A high-risk community sample of 177 adults (89 men; 50.3%) were assessed for childhood trauma exposure, engagement in SDV (e.g., suicide attempts), and ODV (e.g., assault). A cortical delay discounting (C-DD) measure was created using a multivariate additive model of gray matter thickness across both hemispheres, previously found to be positively associated with susceptibility to impulsivity and externalizing disorders. Childhood trauma exposure was positively associated with ODV and SDV; however, these relationships differed as a function of C-DD. Engagement in ODV increased as scores on C-DD increased, and SDV increased as scores on C-DD decreased. Furthermore, moderation revealed biological sex differences, as the association between childhood trauma and SDV depended on C-DD for women but not for men. Findings from the present work demonstrate that risk conferred by childhood trauma exposure to violence varied as a function of a C-DD. Together, these findings point to the utility of neurobiological markers of impulsive decision-making for differentiating risk for violence among individuals with a history of trauma exposure. | |
| Sponsor | This research was supported by the National Science Foundation Graduate Research Fellowship Award, National Institute of Mental Health grants (1R01MH116228-01A1, 1F31MH120936), and a National Institute on Drug Abuse grant (F31DA053782). These institutes had no role in the study design; collection, analysis, or interpretation of the data; writing the manuscript; or the decision to submit the article for publication. The authors would like to acknowledge the team of research associates and undergraduate students who facilitated the collection of these data. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guides on the care and use of laboratory animals. The authors declare no conflicts of interest. The study procedures were approved by the Institutional Review Board of Human Studies Research at the University of Delaware (Protocol Nos.: 1073423-17 and 1361164-1). The present data were disseminated in poster format that Annual Society for Research in Psychopathology conference in September 2022. No further dissemination of the data has been previously presented. The data that support the findings of this study are available from the author Naomi Sadeh upon reasonable request. This study was not preregistered.Ana E. Sheehan served as lead for conceptualization, data curation, formal analysis, investigation, project administration, and writing–original draft and contributed equally to writing–review and editing. Nadia Bounoua contributed equally to formal analysis and funding acquisition and served in a supporting role for conceptualization, project administration, and writing–review and editing. Anna Stumps served in a supporting role for validation, visualization, writing–original draft, and writing–review and editing. Rickie Miglin served in a supporting role for formal analysis, funding acquisition, and writing–review and editing. Wendy Huerta served in a supporting role for visualization and writing–review and editing. Naomi Sadeh served as lead for funding acquisition, resources, and software, contributed equally to conceptualization, and served in a supporting role for investigation, methodology, supervision, writing–original draft, and writing–review and editing. Nadia Bounoua, Rickie Miglin, and Wendy Huerta contributed equally to writing–original draft. | |
| Citation | Sheehan, A. E., Bounoua, N., Stumps, A., Miglin, R., Huerta, W., & Sadeh, N. (2023). Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals. Journal of Psychopathology and Clinical Science, 132(7), 897–907. https://doi.org/10.1037/abn0000857 | |
| ISSN | 2769-755X | |
| URL | https://udspace.udel.edu/handle/19716/33642 | |
| Language | en_US | |
| Publisher | Journal of Psychopathology and Clinical Science | |
| Keywords | violence | |
| Keywords | suicide | |
| Keywords | aggression | |
| Keywords | cortical delay discounting | |
| Keywords | trauma | |
| Title | Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals | |
| Type | Article |
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