Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework
| Author(s) | Arighi, Cecilia N. | |
| Author(s) | Shamovsky, Veronica | |
| Author(s) | Masci, Anna Maria | |
| Author(s) | Ruttenberg, Alan | |
| Author(s) | Smith, Barry | |
| Author(s) | Natale, Darren A. | |
| Author(s) | Wu, Cathy H. | |
| Author(s) | D’Eustachio, Peter | |
| Ordered Author | Cecilia Arighi, Veronica Shamovsky, Anna Maria Masci, Alan Ruttenberg, Barry Smith, Darren A. Natale, Cathy Wu, Peter D’Eustachio | |
| UD Author | Arighi, Cecilia | en_US |
| UD Author | Wu, Cathy | en_US |
| Date Accessioned | 2016-03-29T14:10:39Z | |
| Date Available | 2016-03-29T14:10:39Z | |
| Copyright Date | Copyright © 2015 Arighi et al. | en_US |
| Publication Date | 2015-04-20 | |
| Description | Publisher's PDF. | en_US |
| Abstract | The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set has allowed us to identify species-specific gaps in experimental data and possible functional differences between species, and to employ inferred structural and functional relationships to suggest plausible resolutions of these discrepancies and gaps. | en_US |
| Department | University of Delaware. Center for Bioinformatics & Computational Biology. | en_US |
| Citation | Arighi C, Shamovsky V, Masci AM, Ruttenberg A, Smith B, Natale DA, et al. (2015) Toll- Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework. PLoS ONE 10(4): e0122978. doi:10.1371/journal.pone.0122978 | en_US |
| DOI | DOI:10.1371/journal.pone.0122978 | en_US |
| ISSN | 1932-6203 | en_US |
| URL | http://udspace.udel.edu/handle/19716/17571 | |
| Language | en_US | en_US |
| Publisher | Public Library of Science (PLOS) | en_US |
| dc.rights | CC-BY 4.0 | en_US |
| dc.source | PLOS One | en_US |
| dc.source.uri | http://journals.plos.org/plosone/ | en_US |
| Title | Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework | en_US |
| Type | Article | en_US |
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