The actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos

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Author(s)Testa, Michael D.
Author(s)Remsburg, Carolyn M.
Author(s)Song, Jia L.
Date Accessioned2023-06-14T19:47:00Z
Date Available2023-06-14T19:47:00Z
Publication Date2023-03-21
Description © 2023 by the authors. This article was originally published in microPublication Biology. The version of record is available at: https://doi.org/10.17912/micropub.biology.000717
AbstractFascin is a conserved protein that has been shown to modulate the cytoskeleton. Its role in early development remains unclear. After fertilization, embryos undergo rapid cell divisions, requiring the precise regulation of cytoskeleton to segregate chromosomes. Results indicate that Fascin is in the cell cortex, enriched in the perinuclear region of non-dividing blastomeres and on the mitotic spindle of dividing blastomeres of the early embryo. Loss-of-function of Fascin leads to a significant developmental delay or arrest, indicating that Fascin is important for proper early embryonic development.
SponsorThis work is funded by National Science Foundation (IOS 1553338 and MCB 2103453 to J.L.S.), NIH P20GM103653, NIH NIGMS P20GM103446
CitationTesta, MD; Remsburg, CM; Song, JL (2023). The actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos. microPublication Biology. 10.17912/micropub.biology.000717.
ISSN2578-9430
URLhttps://udspace.udel.edu/handle/19716/32928
Languageen_US
PublishermicroPublication Biology
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
TitleThe actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos
TypeArticle
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