Effects of limited bedding and nesting on postpartum mood state in rats

Simple item page
Author(s)Gifford, Janace J.
Author(s)Pluchino, Jenna R.
Author(s)Della Valle, Rebecca
Author(s)Van Weele, Brooke
Author(s)Brezoczky, Emma
Author(s)Caulfield, Jasmine I.
Author(s)Cavigelli, Sonia A.
Author(s)Schwarz, Jaclyn M.
Date Accessioned2023-06-27T20:37:43Z
Date Available2023-06-27T20:37:43Z
Publication Date2023-04-26
DescriptionThis is the peer reviewed version of the following article: Gifford, JJ, Pluchino, JR, Della Valle, R, et al. Effects of limited bedding and nesting on postpartum mood state in rats. J Neuroendocrinol. 2023;e13275. doi:10.1111/jne.13275, which has been published in final form at https://doi.org/10.1111/jne.13275. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. © 2023 British Society for Neuroendocrinology. This article will be embargoed until 04/26/2024.
AbstractThis study examined the effect of limited bedding and nesting (LBN) stress on postpartum anhedonia, maternal behaviors, anxiety-like behaviors, and neuroendocrine and neuroimmune function as a potential model of postpartum depression. Dams underwent sucrose preference tests prior to breeding, during gestation and again postpartum, to examine the potential onset of anhedonia. On embryonic day 19, dams were placed into either a LBN or control housing condition. Contrary to our predictions, LBN stress had no effect on postpartum sucrose preference. We also found no effect of LBN condition on fecal estradiol or corticosterone levels, both of which increased at birth and decreased postpartum. Regardless of housing conditions, approximately 40% of new mothers exhibited a decrease in sucrose preference, while others show no change, suggesting an individual susceptibility to postpartum anhedonia. In a separate cohort of LBN and control dams, we measured pup retrieval, hoarding behavior, elevated plus maze (EPM), and marble burying. LBN dams exhibited increased anxiety, associated with decreased time spent in the open arms of the EPM. We also measured a significant increase in IL-6 expression in the dorsal hippocampus and medial prefrontal cortex of postpartum dams compared to nonpregnant dams. These findings suggest that while LBN stress has effects on anxiety and maternal care, it does not induce postpartum anhedonia. Rather, there are inherent differences in susceptibility to anhedonia in individual dams, and future studies should be conducted to better understand individual vulnerability and resilience to postpartum anhedonia.
SponsorThis work was supported by the National Institutes of Health (R21MH122862).
CitationGifford, JJ, Pluchino, JR, Della Valle, R, et al. Effects of limited bedding and nesting on postpartum mood state in rats. J Neuroendocrinol. 2023;e13275. doi:10.1111/jne.13275
ISSN1365-2826
URLhttps://udspace.udel.edu/handle/19716/32951
Languageen_US
PublisherJournal of Neuroendocrinology
Keywordsanhedonia
Keywordsanxiety
Keywordslimited bedding and nesting
Keywordspostpartum depression
Keywordssucrose preference
TitleEffects of limited bedding and nesting on postpartum mood state in rats
TypeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Effects of limited bedding and nesting on postpartum mood‐state in rats.pdf
Size:
1.85 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.22 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Publications