Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery
Author(s) | Green, Matthew D. | |
Author(s) | Foster, Abbygail A. | |
Author(s) | Greco, Chad T. | |
Author(s) | Roy, Raghunath | |
Author(s) | Lehr, Rachel M. | |
Author(s) | Epps, Thomas H. III | |
Author(s) | Sullivan, Millicent O. | |
Ordered Author | Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, III and Millicent O. Sullivan | |
UD Author | Green, Matthew D. | en_US |
UD Author | Foster, Abbygail A. | en_US |
UD Author | Greco, Chad T. | en_US |
UD Author | Roy, Raghunath | en_US |
UD Author | Lehr, Rachel M. | en_US |
UD Author | Epps, Thomas H. III | en_US |
UD Author | Sullivan, Millicent O. | en_US |
Date Accessioned | 2016-03-16T15:33:43Z | |
Date Available | 2016-03-16T15:33:43Z | |
Copyright Date | Copyright © The Royal Society of Chemistry 2014. | en_US |
Publication Date | 2014-06-05 | |
Description | Publisher's PDF | en_US |
Abstract | Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging. | en_US |
Department | University of Delaware. Department of Chemical & Biomolecular Engineering. | en_US |
Citation | Thomas III, H. "Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery." Polymer chemistry 5.19 (2014): 5535-5541. | en_US |
DOI | DOI: 10.1039/C4PY00638K | en_US |
ISSN | 1759-9954 ; e- 1759-9962 | en_US |
URL | http://udspace.udel.edu/handle/19716/17509 | |
Language | en_US | en_US |
Publisher | Royal Society of Chemistry | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Polymer Chemistry | en_US |
dc.source.uri | http://www.rsc.org/journals-books-databases/about-journals/polymer-chemistry/ | en_US |
Title | Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery | en_US |
Type | Article | en_US |
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