The impact of dietary omega-3 fatty acids and omega-3 to omega-6 fatty acid ratio on cognitive decline in the healthy aging in neighborhoods of diversity across the lifespan (HANDLS) study sample
| Author(s) | Gerassimakis, Constance S. | |
| Date Accessioned | 2017-12-11T15:45:37Z | |
| Date Available | 2017-12-11T15:45:37Z | |
| Publication Date | 2017 | |
| SWORD Update | 2017-09-06T13:26:26Z | |
| Abstract | Background. Growing evidence suggests an association between decreased dietary intake of omega-3 fatty acids and increased risk for cognitive impairment and cognitive decline. Since the metabolic pathways of omega-3 (n-3) and omega-6 (n-6) fatty acids are mutually competitive, with chiefly antagonistic physiological effects, the ratio of n-3 to n-6 fatty acids may be a better indicator of essential fatty acid status than absolute levels. ☐ Objective. The primary aim of this study was to evaluate the relationship of absolute n-3 fatty acid and relative n-3 to n-6 fatty acid intakes with cognitive decline in an urban biracial population of ages 30-64 years. ☐ Methods. Our study is a prospective longitudinal examination of the relationship of baseline absolute n-3 fatty acid and relative n-3/n-6 dietary intakes with cognitive change between Wave 1 and Wave 3 measured by eleven neuropsychological tests over multiple domains. This study is a secondary analysis of the HANDLS database among those participants (n= 1543) who had a baseline Mini-Mental State Examination total score and two baseline 24-hour dietary recalls. ☐ Results. No relationship was observed between absolute n-3 or n-3/n-6 ratios of fatty acid intakes and cognitive decline in this sample, except for the ratio of n-3 PUFA/n-6 PUFA, which showed a significant negative relationship with Mini-Mental State Examination score rate of cognitive change. ☐ Conclusion. Only one of the relationships tested using the 4 dietary predictors for the 11 cognitive outcomes, was significant. Due to only finding one predictor significant for one outcome, it is likely a type-I error. | en_US |
| Advisor | Kuczmarski, Marie Fanelli | |
| Degree | M.S. | |
| Department | University of Delaware, Department of Behavioral Health and Nutrition | |
| Unique Identifier | 1015200521 | |
| URL | http://udspace.udel.edu/handle/19716/21780 | |
| Language | en | |
| Publisher | University of Delaware | en_US |
| URI | https://search.proquest.com/docview/1958951225?accountid=10457 | |
| Keywords | Psychology | en_US |
| Keywords | Health and environmental sciences | en_US |
| Keywords | Biracial | en_US |
| Keywords | Cognitive change | en_US |
| Keywords | Omega-3 fatty acids | en_US |
| Keywords | Omega-6 fatty acids | en_US |
| Keywords | Ratio | en_US |
| Keywords | Urban | en_US |
| Title | The impact of dietary omega-3 fatty acids and omega-3 to omega-6 fatty acid ratio on cognitive decline in the healthy aging in neighborhoods of diversity across the lifespan (HANDLS) study sample | en_US |
| Type | Thesis | en_US |