Melatonin supplementation does not alter vascular function or oxidative stress in healthy normotensive adults on a high sodium diet
| Author(s) | Ramos Gonzalez, Macarena | |
| Author(s) | Axler, Michael R. | |
| Author(s) | Kaseman, Kathryn E. | |
| Author(s) | Lobene, Andrea J. | |
| Author(s) | Farquhar, William B. | |
| Author(s) | Witman, Melissa A. | |
| Author(s) | Kirkman, Danielle L. | |
| Author(s) | Lennon, Shannon L. | |
| Date Accessioned | 2024-02-21T21:21:54Z | |
| Date Available | 2024-02-21T21:21:54Z | |
| Publication Date | 2023-12-18 | |
| Description | This article was originally published in Physiological Reports. The version of record is available at: https://doi.org/10.14814/phy2.15896. © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. | |
| Abstract | High sodium diets (HSD) can cause vascular dysfunction, in part due to increases in reactive oxygen species (ROS). Melatonin reduces ROS in healthy and clinical populations and may improve vascular function. The purpose was to determine the effect of melatonin supplementation on vascular function and ROS during 10 days of a HSD. We hypothesized that melatonin supplementation during a HSD would improve vascular function and decrease ROS levels compared to HSD alone. Twenty-seven participants (13 M/14 W, 26.7 ± 2.9 years, BMI: 23.6 ± 2.0 kg/m2, BP: 110 ± 9/67 ± 7 mmHg) were randomized to a 10-day HSD (6900 mg sodium/d) supplemented with either 10 mg of melatonin (HSD + MEL) or a placebo (HSD + PL) daily. Brachial artery flow-mediated dilation, a measure of macrovascular function, (HSD + PL: 7.1 ± 3.8%; HSD + MEL: 6.7 ± 3.4%; p = 0.59) and tissue oxygenation index (TSI) reperfusion rate, a measure of microvascular reactivity, (HSD + PL: 0.21 ± 0.06%/s; HSD + MEL: 0.21 ± 0.08%/s; p = 0.97) and TSI area under the curve (HSD + PL: 199899 ± 10,863 a.u.; HSD + MEL: 20315 ± 11,348 a.u.; p = 0.17) were similar at the end of each condition. Neither nitroxide molarity (HSD + PL: 7.8 × 10−5 ± 4.1 × 10−5 mol/L; HSD + MEL: 8.7 × 10−5 ± 5.1 × 10−5 mol/L; p = 0.55) nor free radical number (HSD + PL: 8.0 × 1015 ± 4.4 × 1015; HSD + MEL: 9.0 × 1015 ± 4.9 × 1015; p = 0.51) were different between conditions. Melatonin supplementation did not alter vascular function or ROS levels while on a HSD in this sample of young healthy | |
| Sponsor | This research was supported, in part, by a National Institutes of Health (NIH) grant HL145055 and P20 GM113125. | |
| Citation | Ramos Gonzalez, M., Axler, M. R., Kaseman, K. E., Lobene, A. J., Farquhar, W. B., Witman, M. A., Kirkman, D. L., & Lennon, S. L. (2023). Melatonin supplementation does not alter vascular function or oxidative stress in healthy normotensive adults on a high sodium diet. Physiological Reports, 11, e15896. https://doi.org/10.14814/phy2.15896 | |
| ISSN | 2051-817X | |
| URL | https://udspace.udel.edu/handle/19716/34010 | |
| Language | en_US | |
| Publisher | Physiological Reports | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| Keywords | brachial artery FMD | |
| Keywords | melatonin | |
| Keywords | NIRS | |
| Keywords | oxidative stress | |
| Keywords | sodium | |
| Title | Melatonin supplementation does not alter vascular function or oxidative stress in healthy normotensive adults on a high sodium diet | |
| Type | Article |
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